PPIs interfere with achievement of remission in IBS patients on infliximab: Study
It has been recently observed that patients with inflammatory bowel disease (IBD) taking proton pump inhibitors (PPI) are less likely to achieve remission while on infliximab therapy, according to recent research published in The Gut.
In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. Therefore, Thomas X Lu and associates from the Inflammatory Bowel Disease Center, University of Chicago Medicine, Chicago, USA carried out this study to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD.
Patient-level data of adult patients with moderate-to-severe IBD treated with infliximab were obtained from the Yale Open Data Access Framework. Multivariable analysis and propensity score-matched analysis were performed to assess week 30 remission rates, week 54 remission rates and hospitalisation rates in patients on infliximab therapy with and without PPI exposure.
The authors included a total of 889 patients and 147 patients on infliximab with and without PPI therapy, respectively. Patients on PPI were older, more likely to be Caucasian and were less likely to be on immunomodulator therapy.
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