Single dose of metformin reduces hepatic venous pressure in portal hypertension: Study
Written By : Dr. Nandita Mohan
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2021-08-06 03:30 GMT | Update On 2021-08-06 03:30 GMT
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Portal hypertension is the main determinant of clinical decompensation in patients with liver cirrhosis. In preclinical data metformin lowers portal pressure, but there are no clinical data for this beneficial effect.
One study recently published in the Alimentary Pharmacology and Therapeutics Journal highlighted that a single oral metformin dose acutely reduces hepatic venous pressure gradient (HVPG) in patients with portal hypertension without affecting systemic or liver hemodynamics or inflammatory biomarkers.
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