SIRI may independently forecast severity of Acute Pancreatitis: Study

Published On 2025-04-07 15:15 GMT   |   Update On 2025-04-07 15:16 GMT
Advertisement

A study published in the Journal of Inflammation Research suggests that SIRI may independently forecast the severity of acute pancreatitis.

This study aimed to determine the association of the systemic inflammatory response index (SIRI) with severity in patients with acute pancreatitis (AP). This retrospective study was conducted using clinical data of 1514 patients with acute pancreatitis who were admitted between January 2019 and October 2023 to the First Clinical Medical College of Three Gorges University. SIRI was calculated as peripheral blood neutrophils × monocytes/lymphocytes ratio, and patients were divided into tertiles according to the SIRI levels. The comparison of demographic characteristics, clinical manifestations, laboratory parameters, and outcomes was made among groups. We also carried out multivariate logistic regression to analyze risk factors independently and forecast AP severity. Furthermore, the relationship between SIRI and AP severity was assessed using restricted cubic spline analysis. Subgroup analysis was conducted according to age, sex, body mass index, diabetes, white blood cell count, sequential organ failure assessment score, requirement for continuous renal replacement therapy, and etiology of acute pancreatitis. Results: Among the 1514 enrolled patients, 171 (11.3%) developed severe acute pancreatitis. Higher SIRI levels were independently related to the higher incidence of severe acute pancreatitis (adjusted P < 0.05) after adjusting the possible confounders. Nonlinear curve fitting demonstrated the reverse J-shaped relationship of SIRI with acute pancreatitis severity, with inflection points at 13. A consistent association was observed across various subgroup analyses. SIRI independently forecasts the severity of acute pancreatitis. This readily available biomarker may facilitate early stratification of risk and prompt intervention in clinical practice.

Reference:
Wu, W., Zhang, Y., Zhang, Y., Qu, X., Zhang, Z., & Zhang, R. (2025). Association Between the Systemic Inflammation Response Index and Severity of Acute Pancreatitis: A Retrospective Cohort Study. Journal of Inflammation Research, 18, 4471–4480. https://doi.org/10.2147/JIR.S512553

Keywords:
Wu, W., Zhang, Y., Zhang, Y., Qu, X., Zhang, Z., & Zhang, R, Association, Between, Systemic, Inflammation, Response, Index, Severity, Acute, Pancreatitis, Retrospective, Cohort, Study, Journal of Inflammation Research


Tags:    
Article Source : Journal of Inflammation Research

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Similar News