SIRS score predicts mortality risk of liver cirrhosis patients with hepatic encephalopathy: BMC

The significant independent risk variables were SIRS and a MELD score more than 18 (hazard ratio 4.758, 2.539; 95% CI 2.115–10.703, 1.210–5.331; P < 0.001, P < 0.05, respectively). For SIRS scores of 0, 1, 2, 3, and 4, the corresponding 28-day survival rates were 95.8%, 89.6%, 61.1%, 37.5%, and 12.5% (P < 0.001).

The death rate for patients with a MELD score of < 18 was 30% for those with SIRS and 7% for those without. Mortality was 62% in individuals with SIRS and 16% in patients without SIRS when a MELD score was greater than 18 (P < 0.001). Mortality among uninfected individuals was 43% for those with SIRS and 4% for those without. The death rate among infected patients was 53% among those who satisfied SIRS diagnostic criteria and 19% among those who did not (P < 0.001).

Overall, this research discovered that SIRS is a prevalent, independent risk factor for mortality among hospitalized LC patients with HE, whether or not there is an infection. These findings highlight the significance of HE as an early risk indicator for LC patients' in-hospital HE-related deaths. 

Reference:

Zhang, K., Qu, Z., Tang, R., Dong, H., Fan, J., & Ye, W. (2025). Correlation between systemic inflammatory response syndrome and prognosis of patients with cirrhosis and hepatic encephalopathy. BMC Gastroenterology, 25(1), 536. https://doi.org/10.1186/s12876-025-04141-1