Study finds mesalazine ineffective against irritable bowel syndrome
Sweden: A recent study published in Alimentary Pharmacology and Therapeutics suggests that mesalazine has little effect on irritable bowel syndrome (IBS) symptoms and mucosal patch technology cannot predict a greater likelihood of responding to mesalazine based on rectal measures of immune activity.
The current definition of irritable bowel syndrome, a functional bowel illness, excludes objective biomarkers and is based on the coexistence of stomach discomfort and changed bowel habits that last for at least six months. In the case of irritable bowel syndrome, low-grade immune activity in the gut represents a possible therapeutic target. Valeria Castro Tejera and colleagues undertook this study in order to ascertain if IBS symptoms improve following mesalazine treatment and the usefulness of measurements of immunological activity in the rectal mucosa.
In this randomized, multicenter study, mesalazine 2400 mg or placebo once daily was used as the therapy for eight weeks in participants with IBS (according to Rome III criteria). The main objective was the overall evaluation of a ≥50% or more improvement in IBS symptoms during the intervention period. The IBS severity score method was also used to quantify IBS symptoms, and mucosal patch technology was used to assess immune function. Mesalazine studies for IBS that were randomized, placebo-controlled, and analyzed post hoc were included.
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