Tenapanor shows promise in Irritable bowel syndrome in phase 3 trials: claims study

Data revealed the following facts.

• Of the 629 randomized patients with IBS-C, 606 (96.3%) were included in the intention-to-treat analysis set (tenapanor: n = 307; placebo: n = 299) and 533 (84.7%) completed the 12-week treatment period.
• In the intention-to-treat analysis set (mean age 45 years, 81.4% women), a significantly greater proportion of patients treated with tenapanor met the primary endpoint than patients treated with placebo (27.0% vs 18.7%, P = 0.020).
• Abdominal symptoms and global symptoms of IBS also improved with tenapanor (P < 0.05 vs placebo).
• Diarrhea was the most commonly reported adverse event, resulting in study drug discontinuation in 6.5% and 0.7% of patients receiving tenapanor and placebo, respectively, during the 12-week treatment period.

Observing the results, the team concluded that," In conclusion, tenapanor, with its unique mechanism of action, positive impact on key symptoms and satisfaction measures, and acceptable safety profile, could offer an exciting new treatment option for patients with IBS-C."

For full article follow the link: Chey, W. D., Lembo, A. J., & Rosenbaum, D. P. (2020). Efficacy of Tenapanor in Treating Patients With Irritable Bowel Syndrome With Constipation: A 12-Week, Placebo-Controlled Phase 3 Trial (T3MPO-1). The American journal of gastroenterology, 115(2), 281–293. https://doi.org/10.14309/ajg.0000000000000516

Primary source: The American Journal of Gastroenterology