The AGPR Index - novel non-invasive marker in Chronic Hepatitis B

Researchers from China developed a novel, simple, accurate, and noninvasive marker to predict Liver Fibrosis and Cirrhosis in Chronic Hepatitis B patients. The research was published in the "World Journal of Gastroenterology, 2022." 

Hepatitis B virus affects human health in varied ways. It can cause fibrosis and cirrhosis of the liver leading to Hepatocellular Carcinoma. Due to its considerable necessity, researchers from China conducted a study to develop a Non-invasive, practical, and convenient means of predicting liver fibrosis and cirrhosis. 

As Liver biopsy is the gold standard, they established a new index with parameters like alkaline phosphatase(U/L) + gamma-glutamyl transpeptidase (U/L)/platelet (109/L) (AGPR) to predict liver fibrosis and cirrhosis. Along with this they also compared the area under the receiver operating characteristic curve (AUROC) of AGPR, gamma-glutamyl transpeptidase to platelet ratio, aspartate transaminase to platelet ratio index, and FIB-4 and evaluated the accuracy of these routine laboratory indices in predicting liver fibrosis and cirrhosis.