Transcutaneous Auricular vagus nerve stimulation Effective in Treating Functional Dyspepsia

Among the total 300 patients enrolled, the participants in the V10 and V25 groups demonstrated significantly higher response rates (81.2% and 75.9%, respectively) compared to the sham group (47%). Both V10 and V25 groups also exhibited higher rates of adequate relief (85.1% and 80.8%, respectively) in contrast to the sham group (67%). Also, there was no statistically significant difference between the V10 and V25 groups in terms of response rates and adequate relief. The therapeutic effects of taVNS endured through weeks 8 and 12 of the follow-up period showed its lasting impact, while the adverse events were minimal and comparable across all groups (1%-3%).

This study is the first to demonstrate that a 4-week regimen of taVNS at 10 Hz or 25 Hz  which is both effective and safe for treating adult FD. The findings open new doors for non-invasive neuromodulation techniques in the context of gastrointestinal disorders that provides hope for those seeking relief from the burdens of functional dyspepsia.

Reference:

Shi, X., Zhao, L., Luo, H., Deng, H., Wang, X., Ren, G., Zhang, L., Tao, Q., Liang, S., Liu, N., Huang, X., Zhang, X., Yang, X., Sun, J., Qin, W., Kang, X., Han, Y., Pan, Y., & Fan, D. (2023). Transcutaneous auricular vagal nerve stimulation is effective for the treatment of functional dyspepsia: A multicenter, randomized controlled study. The American Journal of Gastroenterology. https://doi.org/10.14309/ajg.0000000000002548