Trazpiroben shows promise in treatment of gastroparesis, claims study
Trazpiroben was well tolerated with a favourable safety profile, supporting its further development for the treatment of gastroparesis, suggest research findings. The findings have been published in Alimentary Pharmacology & Therapeutics.
Gastroparesis is a chronic gastric motility disorder. Dopamine D2/D3 receptor antagonists metoclopramide and domperidone are current treatment options but are associated with central nervous system and cardiovascular safety concerns, respectively, precluding chronic use. It is well established that dopamine D2/D3 receptor antagonists can reduce the symptoms of gastroparesis. Dopamine antagonists are effective in the establishment of normal gastric myoelectric activity and resolution of gastric dysrhythmias, which are reported to have a more direct relationship to the improvement of symptoms in patients with gastroparesis than gastric emptying alone. Furthermore, dopamine receptor antagonists have a direct antiemetic effect via inhibition of dopamine receptors in the chemoreceptor trigger zone.
Trazpiroben (TAK-906), a dopamine D2/D3 receptor antagonist, is under development for chronic treatment of moderate-to-severe gastroparesis. Nonclinical data suggest trazpiroben will have D2/D3 receptor antagonism comparable with metoclopramide or domperidone.
So, researchers aimed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics (effect on prolactin and gastric function) of twice-daily trazpiroben (5, 25 and 100 mg) in participants with gastroparesis.
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