Vebicorvir associated with Increased viral suppression with in Hepatitis B infection
Vebicorvir was found to increase viral suppression by altering DNA and pregenomic (pg)RNA in Hepatitis B viral infection. It was also found to be safe and tolerable when taken with nucleos(t)ide reverse transcriptase inhibitors as per a study that was published in the Journal of Hepatology.
Total suppression of the hepatitis B virus replication is necessary for finite treatment regimens. Past data has shown persistent viremia during NrtI treatment despite HBV DNA being undetectable as HBV nucleos(t)ide reverse transcriptase inhibitors (NrtIs) do not completely suppress HBV replication. HBV core inhibitors may enhance viral suppression when combined with NrtIs. Vebicorvir (VBR) is a novel inhibitor of the HBV core protein which acts by interfering with two additional steps in HBV replication than NrtIs. Hence researchers conducted a study to evaluate the efficacy and safety of the investigational core inhibitor, vebicorvir (VBR), in virologically- suppressed patients on NrtIs.
Non-cirrhotic, NrtI-suppressed patients with chronic HBV were randomized to VBR 300 mg once daily or matching placebo (PBO) for 24 weeks. Treatment was stratified by hepatitis B e antigen (HBeAg) status. The primary endpoint was a change from the Baseline in serum HBeAg or hepatitis B surface antigen (HBsAg) after 24 weeks.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.