Oxycodone similar to acetaminophen and codeine combination in pain management
Prescribing opioids for chronic pain has increased despite evidence of the association of their long-term use with adverse outcomes. A recent study found that oxycodone (strong opioid) did not provide superior pain relief compared with combination acetaminophen and codeine (mild opioid) after the first 7 days of fracture surgery, despite a 6-fold higher dose of opioid being delivered in the strong opioid group. The study findings were published in the journal JAMA Network Open on November 17, 2021.
Patients with a surgically managed fracture are commonly discharged from the hospital with a strong opioid prescription, but limited evidence exists to support this practice. Therefore, researchers of the University of New South Wales, South Western Sydney Clinical School, Australia, conducted a study to evaluate whether strong opioids provide better analgesia than mild opioids over the first-week post-discharge from hospital after fracture surgical treatment.
Oxycodone Not Superior To Paracetamol, Codeine Combo For Pain Relief After Fracture Surgery: JAMA
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