Cholesterol lowering drugs for high heart risk patients must be added

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2022-05-16 05:30 GMT | Update On 2022-05-16 05:30 GMT

A panel of international experts and patients in The BMJ said that additional cholesterol- lowering drugs should be offered to patients with high levels of 'bad' (LDL) cholesterol who are also at high risk of heart disease.

The drugs assessed by the panel are ezetimibe and PCSK9 inhibitors. They work by reducing the absorption of cholesterol from foods and the production of cholesterol in the body. The recommendations apply to adults already taking the maximum dose of statins or those who are intolerant to statins and are part of The BMJ's 'Rapid Recommendations' initiative - to produce rapid and trustworthy guidance based on new evidence to help doctors make better decisions with their patients.

The panel considered the balance of benefits against the burdens and potential harms of starting a new drug according to patients' level of risk, values and preferences, and their advice represents a shift from the traditional focus on lowering cholesterol levels to a focus on reducing an individual's overall cardiovascular risk.

New evidence from 14 trials involving 83,660 patients shows that ezetimibe and PCSK9 inhibitors probably reduce heart attacks and strokes in patients with very high and high cardiovascular risk, but not in patients with moderate and low cardiovascular risk.

As such, the panel favors ezetimibe over PCSK9 inhibitors, but says "both would provide important benefits for adults in the high and very high-risk group, but would be of little benefit for adults in the low-risk group."

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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Cholesterol lowering drugs for high heart risk patients must be added

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