Chronic Widespread Pain Associated With 75% Higher Hypertension Risk: Study

The findings were striking: individuals with chronic widespread pain had a 75% higher chance of developing high blood pressure compared to those without pain. Those with chronic pain in specific areas-like the abdomen, neck, or back-also showed increased risks, ranging from 16% to 43%. Short-term pain carried a modest 10% increased risk.

Analysis reveals that nearly 12% of the pain-hypertension link can be explained by depression and systemic inflammation, highlighting these as important mediators. Since chronic pain often leads to depression, which itself raises blood pressure, early detection and treatment of mental health conditions may help mitigate this risk.

Lead researcher Dr. Jill Pell from the University of Glasgow emphasized the need for healthcare providers to recognize that patients with chronic pain are at increased risk of hypertension. Managing pain effectively while monitoring blood pressure and mental health could help prevent cardiovascular complications.

While this observational study focuses mainly on middle-aged White adults and cannot prove causation, it underscores the importance of integrated care approaches. Future randomized trials are needed to explore how pain management interventions impact blood pressure, including considering the effects of common pain medications that may influence hypertension.

These insights deepen understanding of the complex interactions between chronic pain, psychological health, inflammation, and cardiovascular disease risk, offering new frontiers for prevention and treatment.

REFERENCE: Pei Qin, Frederick K. Ho, Carlos A. Celis-Morales, Jill P. Pell. Chronic Pain and Hypertension and Mediation Role of Inflammation and Depression. Hypertension, 2025; DOI: 10.1161/HYPERTENSIONAHA.125.25544