COMBINE-Angina Study: Early Metabolic Therapy in Stable Angina - Insights from Dr Arindam Pande

The COMBINE-Angina Study, presented at ESC Congress 2025 and published in the International Journal of Cardiology, explored the impact of early addition of a metabolic modulator in patients with newly diagnosed stable angina who remained symptomatic despite first-line hemodynamic therapy.

In this interview, Dr. Arindam Pande, Senior Consultant Interventional Cardiologist, Medica Superspeciality Hospital, Kolkata, and one of the leading Indian investigators in the study, discusses the rationale behind early combination therapy, the significance of quality-of-life improvements measured by the SAQ-7 score, and the real-world relevance of the study findings for Indian patients with stable angina.

Key discussion points in the interview were:

• Rationale for participating in the COMBINE-Angina Study

• Early metabolic intervention in stable angina

• Understanding SAQ-7 and quality-of-life outcomes

• Clinical relevance of study findings in Indian practice

• Practical takeaways for cardiologists managing stable angina patients