Incidence, potential risk factors and clinical impacts of incomplete device endothelialization
Atrial fibrillation (AF) is known to cause a 4- to 5-fold increased risk of ischemic stroke. Oral anticoagulation with non-vitamin K oral anticoagulants (NOACs) or vitamin K antagonists are popularly recommended first-line treatment for reducing stroke risk, but bleeding complications and nonadherence are barriers to effective anticoagulation therapy.
Device related thrombus (DRT) formation, one of the main concerns after LAAC, is generally reported to be 2–5% cases. Especially, it may develop on the poorly endothelialized device following intervention, and have a potential negative impact on the risk of stroke and thromboembolic events. Now, what poses as risk factors of incomplete device endothelialization?
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