ISCHEMIA Trial: Routine invasive therapy does not reduce MACE

Published On 2022-02-11 13:41 GMT | Update On 2022-02-11 13:41 GMT

The ISCHEMIA trial fails at proving that routine invasive therapy was associated with a reduction in major adverse ischemic events compared with optimal medical therapy among stable patients with moderate ischemia. Ischemia is a serious problem where some part of your body, like your heart or brain, isn't getting enough blood. Approximately 1.5 million cases of ischemic myocardial infarction (MI) occur annually in the United States; the yearly incidence rate is approximately 600 cases per 100,000 people.

The routine invasive therapy was compared with optimal medical therapy among patients with stable ischemic heart disease and moderate to severe myocardial ischemia on noninvasive stress testing in the trial. Patients with stable ischemic heart disease and moderate to severe ischemia were randomized to routine invasive therapy included 2,588 participants versus medical therapy had 2,591.

Results in journal American College of Cardiology concluded among patients with stable ischemic heart disease and moderate to severe ischemia on noninvasive stress testing, routine invasive therapy failed to reduce major adverse cardiac events compared with optimal medical therapy. There was possible enhanced benefit for invasive compared with heart failure/left ventricular dysfunction.

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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ISCHEMIA Trial: Routine invasive therapy does not reduce MACE

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