Journal Club - Elevated serum creatinine levels may up CVD risk in females

Vascular calcification (VC) is known to be a strong predictor of cardiovascular events and all-cause mortality in CVD. Renal dysfunction is closely associated with VC. Serum creatinine as an important indicator of renal function in chronic kidney disease (CKD), is closely related to increased Vascular calcification.

The study was published in the journal BMC Cardiovascular Disorders.

Measuring the levels of serum creatinine would be helpful in the early screening of individuals at high risk of developing cardiovascular disease (CVD). Further, the researchers stress that higher attention is to be given to females' serum creatinine levels in daily clinical practice.

The study included a total of 9067 participants aged more than 45 years. All participants underwent postero-anterior chest X-ray examination for aortic arch calcification diagnosis.

Serum creatinine level in the female AAC group was significantly higher than that in the non-AAC group, while there was no significant difference in male serum creatinine between the two groups.

These results imply that the role of serum creatinine levels in AAC and CVD development remains under recognised and undertreated in the general population. Hence, AAC or asymptomatic CVD risk screening should be given for female with increased serum creatinine levels, especially in individuals concomitant with other CVD risk factors.

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