Low vessel fractional flow reserve after percutaneous coronary intervention to fail

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2022-06-01 03:30 GMT | Update On 2022-06-01 03:30 GMT

Both fractional flow reserve and non-hyperemic pressure ratios are widely used to assess the hemodynamic importance of intermediate coronary artery lesions. While the specific merits of each of these physiological indices have been mainly validated in a pre-percutaneous coronary intervention (PCI) setting, there is increasing interest in the use of either fractional flow reserve or non-hyperemic pressure ratios to assess the direct impact of stent placement on post percutaneous coronary intervention physiology.

The FAST Outcome study is a retrospective cohort study in which patients were recruited from the P- SEARCH registry. The study is published in International Journal of Cardiology. The study aimed to assess the prognostic value of post percutaneous coronary intervention and the incidence of target vessel failure, a composite endpoint of cardiovascular death, spontaneous target vessel myocardial infarction and target vessel revascularization at 5 years follow-up.

Participants were a age of 65 years, 18.2% were diabetic, and 29.1% presented with stable angina. Vessels were categorized into tertiles based on post- percutaneous coronary intervention vessel fractional flow reserve low ( <0.88), middle ( 0.88–0.93), and upper (≥0.94). Vessels in the lower and middle tertile were more often left anterior descending and had smaller stent diameters.

Vessels in the lower and middle tertile had a higher risk of target vessel failure as compared to vessels in the upper tertile (24.6% and 21.5% vs. 17.1% and 1.58 at 5-years follow-up. Additionally, vessels in the lower tertile had higher rates of target vessel revascularization as compared to vessels in the higher tertile (12.6% vs. 6.5%). Researchers concluded that Lower post - percutaneous coronary intervention vessel fractional flow reserve values are associated with a significantly increased risk of target vessel failure and target vessel revascularization at 5-years follow-up.

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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Low vessel fractional flow reserve after percutaneous coronary intervention to fail

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