Myocardial fibrosis to affect cardiovascular structure and function
Cardiac disease management and diagnosis is crucial to prevent cardiac mortality rate. Myocardial fibrosis, measured using cardiovascular magnetic resonance extracellular volume (ECV), is associated with adverse outcome in heart failure with preserved ejection fraction (HFpEF), but the mechanisms by which myocardial fibrosis exerts this deleterious effect are unclear.
Research square reports study that determines whether myocardial fibrosis causes changes in cardiovascular structure and function, circulating biomarkers and functional status. According to the study, the regression of myocardial fibrosis was associated with improvements in functional status. The small improvement in Left Ventricular Ejection Fraction was not mediated by myocardial fibrosis regression.
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