Oral inhalation flecainide may help restore sinus rhythm in atrial fibrillation patients

Netherlands: A recent study in the journal Circulation: Arrhythmia and Electrophysiology found the administration of flecainide via oral inhalation to be safe and feasible for the conversion of recent-onset atrial fibrillation to sinus rhythm (SR). Also, it was potentially effective in acute care settings.

Currently, oral and intravenous flecainide is recommended for cardioversion of atrial fibrillation. Harry J G M Crijns, Maastricht University Medical Center and CARIM, Maastricht, the Netherlands, and colleagues aimed to evaluate the feasibility of delivering flecainide via oral inhalation (flecainide acetate inhalation solution) for acute conversion in an open-label, dose-escalation study. The researchers hypothesized that delivery of flecainide by oral inhalation would quickly reach plasma concentrations sufficient for restoring sinus rhythm in patients with recent-onset atrial fibrillation.

For more details, checkout full story on the link mention below

Oral Inhalation Flecainide May Help Restore Sinus Rhythm In Atrial Fibrillation Patients