Orion – 4 trial: Inclisiran effective in reducing cholesterol
Inclisiran is a popular drug, studied for its effect to control bad cholesterol or LDL levels in blood, a proprotein convertase subtilisin/kexin type synthesis inhibitor which has been found to reduce LDL-cholesterol by about 50-60%. High cholesterol is a serious health issue that needs to be managed immediately, several medications to prevent cholesterol levels in blood are presently available in market.
ORION-4 in ClinicalTrials.gov investigated the effects of inclisiran on major adverse cardiovascular events. Approximately 15,000 participants aged 55 years or older with pre-existing atherosclerotic cardiovascular disease were randomized between inclisiran sodium 300 mg and matching placebo (given by subcutaneous injection on the day of randomization, at 3 months and then every 6-months) in a 1:1 ratio for a planned median duration of about 5 years. So far inclisiran is effective in preventing heart attacks and strokes.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.