Outcomes of pregnancy in women with hypertrophic cardiomyopathy

 A total of 18 studies with 1624 pregnancies. The incidence of maternal death was 0.2%. The rates of sustained ventricular tachycardia, any ventricular tachycardia (including non-sustained), atrial fibrillation, heart failure, and syncope were 1% (0–1%), 6% (4–8%), 4% (2–6%), 5% (3–8%), and 9% (3–14%), respectively. Postpartum hemorrhage, preeclampsia/eclampsia, and cesarean section complicated 2% (1–4%), 4% (2–6%), and 43% (32–54%) of pregnancies, respectively. Neonatal death occurred in 0.2% of pregnancies. Stillbirth complicated 1% (95% CI, 0–3%) of pregnancies, whereas the incidence of preterm birth was 22% (95% CI, 18–25%).

Researchers concluded that women with hypertrophic cardiomyopathy considering pregnancy can be reassured that the risk of maternal, fetal, or neonatal death is low. However, they are at risk of several non-fatal cardiac and pregnancy-related complications.