PARADISE MI Trial: sacubitril/valsartan effective for heart attack
The PARADISE -MI trial assesed the efficacy and safety of sacubitril/valsartan compared with ramipril in a contemporary acute myocardial infarction population. Heart attack is an extremely dangerous condition with significant mortality rate. The lack of blood flow can occur because of many different factors but is usually related to a blockage in one or more of arteries.
A total of 2,830 in sacubitril/valsartan (target dose 97/103 mg twice a day) or 2,831 ramipril (target 5 mg twice a day) were grouped. The primary outcome of cardiovascular (CV) death, first Heart Failure hospitalization, or outpatient Heart Failure for sacubitril/valsartan vs. ramipril, was: 11.9% vs. 13.2%.
The results of this trial in American College of Cardiology indicates that the combination sacubitril/valsartan did not reduce the primary endpoint in a contemporary enriched acute myocardial infarction population, compared with ramipril. These are interesting findings and add to the available data with angiotensin receptor-neprilysin inhibitors.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.