Weight Loss Drugs May Lower Risk of Heart Failure Hospitalization and Death by 40 Percent: Study
A new large-scale study published in JAMA and presented at the European Society of Cardiology Congress reveals that glucagon-like peptide-1 (GLP-1) targeting medications—specifically semaglutide and tirzepatide may significantly reduce the risk of hospitalization and death in patients with heart failure with preserved ejection fraction (HFpEF), obesity, and type 2 diabetes. The research, conducted by a team from Mass General Brigham, analyzed real-world data from over 90,000 patients, marking the most comprehensive evaluation of these drugs for heart failure with preserved ejection fraction to date.
Heart failure with preserved ejection fraction is the most common form of heart failure, particularly among individuals with obesity and type 2 diabetes, yet effective treatment options remain limited. While semaglutide and tirzepatide are widely recognized for their benefits in weight loss and blood sugar control, their impact on serious heart failure outcomes had not been extensively studied in large populations—until now.
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