Cell free DNA as diagnosing tool in trisomies 21, 18 and 13 during pregnancy
Cell-free DNA or cfDNA is a non-encapsulated DNA in the blood stream that has its been highlighted used as a diagnosing too. A portion of that cell-free DNA originates from a tumor clone and is called circulating tumor DNA (or ctDNA).
This was the first study to assess Cell-free DNA screening performance using genetic confirmation in a prospective obstetrical population. It adds valuable information on test performance in women at a low risk for aneuploidy and in cases with failed Cell-free DNA tests. Study findings are published in American Journal of Obstetrics and Gynecology. Cell-free DNA noninvasive prenatal screening for trisomies 21, 18, and 13 has been rapidly adopted into clinical practice.
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