Top Medical News 1/June/2022

Here are the top medical news for today:

Outcomes of pregnancy in women with hypertrophic cardiomyopathy               

A systematic review of maternal and fetal outcomes of pregnancy in patients with hypertrophic cardiomyopathy published in International Journal of Cardiology. A literature search for studies reporting maternal or fetal outcomes in pregnant women with hypertrophic cardiomyopathy was done. Primary outcomes included maternal death, stillbirth, and fetal death. Secondary maternal outcomes included both sustained and non-sustained ventricular tachycardia (VT), atrial fibrillation, heart failure (HF), syncope, cesarean delivery, and preeclampsia/eclampsia. The secondary fetal outcome was preterm birth.

Researchers concluded that women with hypertrophic cardiomyopathy considering pregnancy can be reassured that the risk of maternal, fetal, or neonatal death is low. However, they are at risk of several non-fatal cardiac and pregnancy-related complications.

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Outcomes of pregnancy in women with hypertrophic cardiomyopathy   

 Low vessel fractional flow reserve after percutaneous coronary intervention to fail: The FAST study    

Both fractional flow reserve and non-hyperemic pressure ratios are widely used to assess the hemodynamic importance of intermediate coronary artery lesions. While the specific merits of each of these physiological indices have been mainly validated in a pre-percutaneous coronary intervention (PCI) setting, there is increasing interest in the use of either fractional flow reserve or non-hyperemic pressure ratios to assess the direct impact of stent placement on post percutaneous coronary intervention physiology.

The FAST Outcome study is a retrospective cohort study in which patients were recruited from the P- SEARCH registry. The study is published in International Journal of Cardiology. The study aimed to assess the prognostic value of post percutaneous coronary intervention and the incidence of target vessel failure, a composite endpoint of cardiovascular death, spontaneous target vessel myocardial infarction and target vessel revascularization at 5 years follow-up.

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Low vessel fractional flow reserve after percutaneous coronary intervention to fail

Late Preterm Birth and Gestational Age Linked to Cardiometabolic Risk in Childhood  

A new study findings in JAMA Network Open suggest that because the cardiometabolic risk score tracks risk from childhood into adulthood, late preterm and moderately preterm birth may be important risk factors for cardiometabolic disorders later in life.

The long-term cardiometabolic consequences of late preterm birth (34-36 weeks' gestation) are not well understood. To assess whether late preterm birth and size for gestational age are associated with cardiometabolic risk in childhood the recent study was conducted.

The retrospective cohort study included 1742 children born in Ontario. Participants were excluded if they had conditions affecting growth, any acute or chronic conditions (other than asthma and high-functioning autism), severe developmental delay, or families who were unable to communicate in English. The primary outcome was composite cardiometabolic risk score. Secondary outcomes were the individual cardiometabolic risk components.

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Late Preterm Birth and Gestational Age Linked to Cardiometabolic Risk in Childhood 

 Risk factors for Lower Gastrointestinal Bleeding   

n this systematic review published JAMA Network Open, reports the risk scores for lower gastrointestinal bleeding, the Oakland score was the most discriminative for predicting safe discharge, major bleeding, and need for transfusion, whereas the Strate score was the best at predicting need for hemostasis.

Clinical prediction models, or risk scores, can be used to risk stratify patients with lower gastrointestinal bleeding, although the most discriminative score is unknown. Observational and interventional studies deriving or validating a lower gastrointestinal bleeding risk score for the prediction of a clinical outcome were included. Studies including patients younger than 16 years or limited to a specific patient population or a specific cause of bleeding were excluded. Two investigators independently screened the studies, and disagreements were resolved by consensus.

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Risk factors for Lower Gastrointestinal Bleeding