Multidrug-resistant bacteria discovered

The emergence and global spread of antimicrobial resistant bacteria among companion animals (e.g., dogs and cats) pose a risk of the animals being reservoirs for cross-species transmission because of their close contact with humans.

In Japan, for the first time, a research team led by 1Associate Professor Mayo Yasugi from the Osaka Metropolitan University Graduate School of Veterinary Science discovered Escherichia coli resistant to both 2colistin and third-generation cephalosporin antibiotics in a companion dog. Outside Japan, both colistin and third-generation cephalosporin-resistant E. coli isolates have already been discovered in companion animals. However, the number of reports is still low, and knowledge of the trends and in-depth analysis of the bacteria is limited. Therefore, there are still many unknowns regarding the nature and 3host-to-host transmission of the bacteria.

This study investigated 678 bacterial strains isolated from 428 dogs and 74 cats with suspected infectious diseases that were presented to the4 Veterinary Medical Center, Osaka Metropolitan University. Researchers discovered two E. coli strains carrying both a mobile colistin-resistant mcr gene and a third-generation cephalosporin-resistant blaCTX gene. One of these strains isolated from a dog was found to be resistant to both colistin and third-generation cephalosporins.

Reference:

Genetic and phenotypic analyses of mcr-harboring extended-spectrum β-lactamase producing Escherichia coli isolates from companion dogs and cats in Japan,Veterinary Microbiology, DOI 10.1016/j.vetmic.2023.109695