Research Identifies Cause of Lupus and Possible Reversal Technique
Northwestern Medicine and Brigham and Women's Hospital scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and show that reversing this defect may potentially reverse the disease.
The study was published in the journal Nature.
Lupus affects more than 5 million people worldwide. Until now, the causes of this disease were unclear. Lupus can lead to life-threatening damage to multiple organs, including the kidneys, brain, and heart. Existing treatments often fail to control the disease effectively and have unintended side effects, such as reducing the immune system’s ability to fight infections.
In the study, scientists discovered a new pathway that causes lupus. They found changes in multiple molecules in the blood of lupus patients. These changes lead to a lack of activation in a pathway controlled by the aryl hydrocarbon receptor (AHR), which usually helps cells respond to environmental pollutants, bacteria, or metabolites. When AHR is not properly activated, it results in too many immune cells called T peripheral helper cells, which promote the production of harmful autoantibodies that cause the disease.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.