Breakthrough in Kidney Health: New Biomarkers Enhance Early Detection and Monitoring, Study Shows
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Drug-induced kidney injury, or nephrotoxicity, is a common complication in clinical medicine that happens when certain drugs at certain doses damage the kidneys. Nephrotoxicity can occur with multiple types of medicines, including anti-inflammatory, antibacterial, antiretroviral, or chemotherapeutic medicines and can lead to therapies being discontinued or restricted from patients. The findings from this collaboration were published recently in Clinical Pharmacology & Therapeutics.
Critical Path Institute® (C-Path) and Boston Medical Center (BMC) published results for six biomarkers that could improve the early and accurate detection of kidney injury, leading to both the development of safer medications and better health outcomes for all patients.
The research team examined urinary levels of protein biomarkers in healthy volunteers and patients undergoing treatment for mesothelioma with a chemotherapy drug that is known to have toxic effects on the kidneys. This enabled the researchers to better understand how kidney function changes in response to injury.
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