Is it really healthy to restrict protein intake for kidney transplant recipients?

Conventional wisdom holds that low protein intake is essential for kidney disease patients. However, scientists from Osaka Metropolitan University demonstrated that it might not always be the case with their recent study on the relationship between protein intake and skeletal muscle mass in kidney transplant recipients.

Since excessive protein intake worsens kidney function, it is commonly believed that patients with chronic kidney disease, including kidney transplant recipients, should limit protein intake to protect their kidneys. On the other hand, it has been suggested that severe protein restriction may worsen sarcopenia and adversely affect prognosis.

Since nutrition and exercise therapy are recommended to improve sarcopenia, protein intake is suspected to relate to the recovery of skeletal muscle mass after kidney transplantation. However, few studies have examined the relationship between skeletal muscle mass and protein intake in kidney transplant recipients.

Responding to this gap, the research group investigated the relationship between changes in skeletal muscle mass-measured by bioelectrical impedance analysis-and protein intake, which was estimated from the urine collected from 64 kidney transplant recipients 12 months after kidney transplantation. The results showed that changes in skeletal muscle mass during this period were positively correlated with protein intake, and that insufficient protein intake resulted in decreased muscle mass.

Reference:

Akihiro Kosoku et al,Influence of protein intake on the changes in skeletal muscle mass after kidney transplantation,Clinical Nutrition,DOI: 10.1016/j.clnu.2022.07.028