Aneurysm rupture risk prediction model developed
Written By : Isra Zaman
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2022-10-12 04:00 GMT | Update On 2022-10-12 04:00 GMT
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Predicting the rupture of aneurysms is crucial for medical prevention and treatment. In Physics of Fluids, researchers from the Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, and the Indian Institute of Technology Madras, developed a patient-specific mathematical model to examine what aneurysm parameters influence rupture risk prior to surgery.
Aneurysms occur when the weakest point of a blood vessel thins, expands, and, after a certain limit, bursts. In the case of cerebral aneurysms such as internal carotid artery bifurcation aneurysm, blood leaks into the intracranial cavity.
"The current study is a sincere and systematic attempt to address the dynamics of blood flow at various stages to understand the initiation, progression, and rupture risk," said B. Jayanand Sudhir, of the Sree Chitra Tirunal Institute for Medical Sciences and Technology.
The team examined the aspect ratio and size ratio of aneurysms, which describe the shape and size characteristics of the bulge in a holistic manner. As these parameters increase and the aneurysm expands, the stress applied against the aneurysm walls and the time blood spends within the aneurysm increase. This leads the probability of rupture to rise.
Patient-specific computed tomography scans are fed into the model, which reconstructs the geometry and blood flow of the aneurysm. It then uses mathematical equations to describe the fluid flow, generating information about the blood vessel walls and blood flow patterns.
Reference:
"Influence of morphological parameters on hemodynamics in internal carotid artery bifurcation aneurysms," is authored by Mahesh S. Nagargoje, Chanikya Valeti, N. Manjunath, Bhushan Akhade, B.J. Sudhir, B.S.V. Patnaik, and Santhosh K. Kannath. The article will appear in Physics of Fluids on Oct. 11, 2022 (DOI: 10.1063/5.0117879). After that date, it can be accessed at https://doi.org/10.1063/5.0117879.
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