Association between Clinical Features and MRI Findings in Patients with Temporal Lobe Epilepsy

A total of 90 patients were included with the mean age of the study population being 29 years. Females comprised 45% of the total sample. Mesial temporal sclerosis (MTS) was the most common imaging finding in about 60% of patients. Four out of five patients had aura whereas 70% had automatisms.

The findings highlighted that the presence of aura in temporal lobe epilepsy patients was significantly associated with Mesial temporal sclerosis on MRI. The presence of automatism and history of childhood febrile seizure did not have a significant association with any specific etiological findings on MRI. The presence of dual pathology on MRI was associated with drug-refractory epilepsy.

The researchers concluded presence of aura and drug-refractory epilepsy both actually point towards the presence of Mesial temporal sclerosis. Dual pathology, on MRI, in temporal lobe epilepsy patients may be a risk factor for drug-refractory epilepsy.

Reference:

Ojha V, Mani A, Basu D, et al. Association between Clinical Features and Magnetic Resonance Imaging Findings in Patients with Temporal Lobe Epilepsy. J Assoc Physicians India 2022;70(11):13–17.