Even Low Lead Exposure May Accelerate Memory Loss in Children: Study Finds

Researchers examined how blood lead levels, both prenatally and during early childhood, affected memory retention. Using an advanced statistical model known as the nonlinear modified power function, the team discovered a clear link between higher childhood lead exposure (ages 4-6) and an accelerated rate of forgetting even at relatively low median blood lead levels around 1.7 µg/dL.

Importantly, the study introduces a translational approach using operant cognitive testing more commonly employed in animal toxicology studies. “Our work advances the current literature by incorporating operant tests specifically the DMTS which are commonly used in animal toxicology studies but sparse in human studies,” added Dr. Jamil M. Lane, co-first author.

The findings reinforce the urgent need for public health interventions to reduce childhood lead exposure, particularly in marginalized communities disproportionately affected by environmental hazards.

Reference: Katherine Svensson et al., Developmental Pb exposure increases rate of forgetting on a delayed matching-to-sample task among Mexican children.Sci. Adv.11,eadq4495(2025).DOI:10.1126/sciadv.adq4495