In a peer-reviewed Perspective (review) article, researchers at the University of Nebraska Medical Center have uncovered concerning evidence that commonly prescribed
medications may interfere with crucial brain development processes by disrupting sterol
biosynthesis. Their findings, published in
Brain Medicine suggest that this previously overlooked mechanism could have significant implications for medication safety during pregnancy and early development.
"What we've discovered is that many prescription medications, while designed for entirely different purposes, can inadvertently interfere with the brain's ability to produce and process sterols, including cholesterol," explains Professor Károly Mirnics, lead author of the review. "This is particularly concerning because the brain requires precise sterol regulation for proper development and function."
The research reveals that the
brain, which contains 25% of the body's cholesterol despite representing only 2% of body weight, maintains its own independent cholesterol production system behind the blood-brain barrier. This process is essential for numerous developmental processes, including nerve cell connection formation and myelin production.
The researchers emphasize that patients should not discontinue prescribed medications without consulting their healthcare providers. However, they recommend that additional research is needed to fully understand the implications of these findings and to develop more targeted approaches for vulnerable populations.
Ref: Korade Z, Heffer M, Mirnics K. Medication effects on developmental sterol biosynthesis. Mol Psychiatry. 2022 Jan;27(1):490-501. doi: 10.1038/s41380-021-01074-5. Epub 2021 Apr 5. PMID: 33820938; PMCID: PMC8490477.
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