Exercise associated with decreased stress associated neural activity

A recent study found that exercise is associated with dose-dependent increases in mPFC activity. This effect does not directly reduce MACE risk; however, it may reduce MACE risk via its regulatory action on SNA.

The study was a Self-reported physical activity data were obtained from Partners Biobank participants and total metabolic equivalents-minutes per week (MET-min/wk) were calculated. In a subset with clinical 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging, Amyg and mPFC activity were measured and corrected by whole cerebrum activity. SNA was calculated (Amyg/mPFC activity). MACE and cardiovascular risk factors were obtained using International Classification of Diseases codes.