Journal Club: Dual Trigger in IVF- A SWOT Analysis
Written By : Dr. Garima Soni
Written By : Dr. Nandita Mohan
Published On 2025-03-31 02:45 GMT | Update On 2025-03-31 07:20 GMT
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A recent review article published in the Fertility Science Research journal published by Scientific Scholar.
The gold standard agent for inducing final oocyte maturation and resumption of meiosis in in vitro fertilisation (IVF) has historically been human chorionic gonadotropin (hCG), which acts as a surrogate for the physiological spontaneous luteinising hormone (LH) surge. Gonadotrophic releasing hormone (GnRH) agonists (GnRHa) were introduced as an alternative trigger in GnRH antagonist cycles, specifically with the advantage of a reduced risk of ovarian hyperstimulation syndrome.
However, the use of GnRH agonist trigger alone is associated with poor corpus luteum development, causing impaired endometrial receptivity and a reduced chance of successful implantation. Subsequently, A combination of a bolus of GnRHa and hCG (dual trigger) was proposed to improve IVF cycle outcomes, especially in poor and normo-responder patients.
Different studies with significant heterogeneity have reported conflicting data about the effect of this trigger combination on various outcome parameters.
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