Exercise amplifies immune attack on pancreatic cancer

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2022-06-06 03:30 GMT | Update On 2022-06-06 03:30 GMT

Aerobics as an exercise always helps us reprogram our immune system and this has shown to even reduce pancreatic tumor growth thereby amplifying the effects of immunotherapy.

The study is Published in the Cancer Cell journal, and it provides new insight into how the body`s immune system which is designed to attack foreign invaders like bacteria, can also recognize cancer cells as abnormal. Exercise-induced increases in levels of the hormone adrenalin cause changes to the immune system, including in the activity of cells that respond to signaling protein interleukin-15.

The current study found that exercise promotes the survival of CD8 T cells sensitive to IL-15, and doubles the number of them homing to pancreatic ductal adenocarcinoma (PDAC) tumors. Such "effector" T cells have been shown by other studies to be capable of killing cancer cells.

Other tests found that aerobic exercise for 30 minutes five times a week reduced the rate of cancer formation by 50 percent in pancreatic ductal adenocarcinoma, and reduced tumor weight by 25 percent in another.

Hence the authors concluded that aerobic exercise affects the immune microenvironment within pancreatic tumors.

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Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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Exercise amplifies immune attack on pancreatic cancer

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