Link between COVID-19 vaccination and breakthrough infections, complications in cancer patients
Patients with cancer are known to have increased risk of COVID-19 complications, including death.In a recent study, published in JAMA Oncology, the researchers have found that patients with cancer had greater risk of SARS-CoV-2 infection and worse outcomes than patients without cancer, and the risk was highest for patients with hematologic cancer and any patients with cancer receiving active treatment. It was also found that triple vaccination was associated with lower risk of poor outcomes.
Reports have shown reduced seroresponse following vaccination in patients with cancer. As such, in this study the team hypothesized that patients with cancer have worse outcome after vaccination, with greater breakthrough infections and worse COVID-19 outcomes, particularly for patients with hematologic cancer.
In this large population-based cohort study, they set out to examine the relative risk of SARS-CoV-2 breakthrough infections and COVID-19 outcomes in vaccinated patients with cancer vs matched noncancer controls, and separately, in those with hematologic vs solid cancer.
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