NRG Oncology Study Affirms Radiotherapy's Role After Radical Hysterectomy in Early Cervical Cancer
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Results from the NRG Oncology GOG-0263 phase III clinical trial testing the addition of cisplatin-based chemotherapy to adjuvant radiotherapy following radical hysterectomy and lymphadenectomy for patients with early-stage, intermediate-risk cervical carcinoma indicated that the addition of chemotherapy did not improve outcomes for patients and led to increased toxicity for patients. The outcomes of this trial support the use of the current standard of care using adjuvant radiotherapy alone following surgery.
The trial accrued 316 eligible patients with early-stage disease and intermediate-risk factors including a combination of histopathologic factors such as capillary lymphatic space involvement, stromal invasion, and tumor size. Accrued patients had radical hysterectomy prior to enrollment onto the study. Trial participants were randomly assigned to receive either adjuvant chemo-radiotherapy (CRT) or radiotherapy alone (RT).
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