Obesity to influence the risk of endometrial cancer progression

A recent study suggests that increased adiposity is a likely contributor to accelerated endometrial cancer (EC) growth and proliferation. Further, the intra tumoral and paracrine adipose environments were found to have EC cell growth and proliferation. Also, there was a presence of endocrine effects but were sporadic with less impact on the tumorigenic pathways studied.

The findings of the study are published in Gynecologic Oncology journal.

The annual incidence of endometrial cancer (EC) is estimated to increase by1–2%. Currently, more than half of all endometrioid EC diagnoses are attributable to obesity -- an independent risk factor for EC. Multiple epidemiologic studies have shown that obesity significantly increases the risk of several cancer types, however, there is no clarity on the mechanisms by which obesity contributes to EC progression.

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Adiposity tied to increased progression of endometrial cancer, study finds