Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • Medical Jobs
  • Medical Matrimony
  • MD Brand Connect
  • MDTV
    • Anesthesia
    • CTVS
    • Cardiology
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • Diet and nutrition
    • ENT
    • Gastroenterology
    • Health Dialogues
    • Health News today
    • Health Shorts
    • Health Updates
    • Health video of the day
    • Laboratory Medicine
    • Latest Videos
    • Latest Webinars
    • MD shorts
    • Medical News Today
    • Medical Updates
    • Medical Video of the day
    • Medicine
    • Medico Legal Update
    • Nephrology
    • Neurology and Neurosurgery
    • Obstetrics and Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics & Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Top Videos
    • Urology
Medical Dialogues
  • Medical News
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • MCI News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Medical Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
    • Pharmacy Education News
  • MDTV
      • Anesthesia
      • CTVS
      • Cardiology
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • Diet and nutrition
      • ENT
      • Gastroenterology
      • Health Dialogues
      • Health News today
      • Health Shorts
      • Health Updates
      • Health video of the day
      • Laboratory Medicine
      • Latest Videos
      • Latest Webinars
      • MD shorts
      • Medical News Today
      • Medical Updates
      • Medical Video of the day
      • Medicine
      • Medico Legal Update
      • Nephrology
      • Neurology and Neurosurgery
      • Obstetrics and Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics & Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Top Videos
      • Urology
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • MCI News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Medical Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Aborad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
  • Case of the Day
  • Editorial
  • Home
  • Oncology
  • Oncology News
  • Adiposity tied to...

Adiposity tied to increased progression of endometrial cancer, study finds

Medha BaranwalWritten by Medha Baranwal Published On 2022-02-26T09:00:41+05:30  |  Updated On 2022-02-26T09:01:04+05:30
Adiposity tied to increased progression of endometrial cancer, study finds
  • Facebook
  • Twitter
  • Whatsapp
  • Telegram
  • Linkedin
  • Email
  • koo
  • Facebook
  • Twitter
  • Whatsapp
  • Telegram
  • Linkedin
  • Email
  • koo
  • Facebook
  • Twitter
  • Whatsapp
  • Telegram
  • Linkedin
  • Email
  • koo

USA: Results from a recent study in the journal Gynecologic Oncology suggest that increased adiposity is a likely contributor to accelerated endometrial cancer (EC) growth and proliferation. Further, the intratumoral and paracrine adipose environments were found to have EC cell growth and proliferation. Also, there was a presence of endocrine effects but were sporadic with less impact on...

USA: Results from a recent study in the journal Gynecologic Oncology suggest that increased adiposity is a likely contributor to accelerated endometrial cancer (EC) growth and proliferation. Further, the intratumoral and paracrine adipose environments were found to have EC cell growth and proliferation. Also, there was a presence of endocrine effects but were sporadic with less impact on the tumorigenic pathways studied. 

The annual incidence of endometrial cancer (EC) is estimated to increase by1–2%. Currently, more than half of all endometrioid EC diagnoses are attributable to obesity -- an independent risk factor for EC. Multiple epidemiologic studies have shown that obesity significantly increases the risk of several cancer types, however, there is no clarity on the mechanisms by which obesity contributes to EC progression.

Considering the above, Logan Blankenship, UT Health Science Center, San Antonio, and colleagues aimed to compare the effects of adiposity on endometrioid endometrial cancer cells in a paracrine, endocrine, and intratumoral environment both in-vitro and in vivo.

For this purpose, the researchers collected all patient samples, EC tissue, serum, and adipose tissue through the institutional tumor registry under IRB approval. For a paracrine-like environment representation, primary EC tissue-derived cells and established EC cell lines were treated with primary adipocyte conditioned medium (ADP-CM) and co-cultured together in a communicating chamber (co-culture assay). By culturing primary and established EC cells in low vs. high BMI patient serum, the endocrine effect was mimicked. 

The effect of adiposity on EC cells was determined. Using RNA-seq, Western blotting, RT-qPCR, and reporter assays, mechanistic studies were conducted. To look at the effect of the tumor microenvironment in vivo, xenograft models were used in which cancer cells were co-implanted with or without adipocytes. 

Following were the salient findings of the study:

  • Treatment of established and primary EC cells with ADP-CM, co-culture, and stimulation with high BMI patient serum increased EC proliferation, long-term colony formation, and growth of EC organoid models.
  • Mechanistic studies showed that all three environments also enhanced the expression of several oncogenic signaling pathways including STAT3, mTOR, Akt, and MAPK in EC cells.
  • RNA-seq studies showed that ADP-CM treatment significantly altered the expression of 209 genes compared to control.
  • Gene set enrichment (GSEA) analysis showed that ADP-CM regulated genes positively correlated with cytokine and STAT3 mediated signaling pathways, stem cells, inflammation, TGFβ, and interferon signaling pathways.
  • In xenograft assays using SCID mice, co-implantation of EC cells with adipose cells significantly enhanced EC tumor growth in vivo.

"The findings can help to focus future study on pathways affected by visceral adipose at the tumoral level in obese patients to find new targets for future therapies," the authors concluded.

Reference:

The study titled, "The role of adiposity in endometrioid endometrial cancer," was published in the journal Gynecologic Oncology.

DOI: https://doi.org/10.1016/j.ygyno.2021.10.049


endometrial cancer adiposity Gynecologic Oncology 
Source : Gynecologic Oncology
Medha Baranwal
Medha Baranwal

    Medha, MSc. Biotechnology

    Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751

    Show Full Article
    Next Story
    Similar Posts
    NO DATA FOUND

    Editorial

    Safeguarding Mental Health of Doctors & How They Can Prevent a Burnout

    Safeguarding Mental Health of Doctors & How They Can Prevent a Burnout

    Analyzing the Role of Levofloxacin in Urinary Tract Infections-A review

    Analyzing the Role of Levofloxacin in Urinary Tract Infections-A review

    Management of Allergic Rhinitis during COVID-19 Pandemic

    Management of Allergic Rhinitis during COVID-19 Pandemic

    Role of Probiotics in recurrent bacterial vaginosis: A review

    Role of Probiotics in recurrent bacterial vaginosis: A review

    Decoding the correct diagnosis of Allergic Rhinitis in clinic practice - Dr Tushar Kanti Ghosh

    Decoding the correct diagnosis of Allergic Rhinitis in clinic practice - Dr Tushar Kanti Ghosh

    View All

    Journal Club Today

    Rivaroxaban effective in treating VTE in symptomatic peripheral artery disease after lower extremity

    Rivaroxaban effective in treating VTE in symptomatic peripheral artery disease after lower extremity

    View All

    Health News Today

    Health Bulletin 30/June/2022

    Health Bulletin 30/June/2022

    View All
    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok
    X
    X