Progression-free survival in advanced melanoma improved by Cell therapy
Written By : Isra Zaman
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2022-09-12 04:15 GMT | Update On 2022-09-12 04:15 GMT
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A novel treatment strategy with personalized cell therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma, according to ground-breaking results reported at the ESMO Congress 2022 from the phase 3 M14TIL trial.
The treatment essentially involves taking a small sample from a patient's resected tumor, growing immune T cells from the tumor in the laboratory and then infusing the personalized TIL therapy back into the patient following chemotherapy. TILs recognize tumor cells as abnormal, penetrate them and then work to kill them.
The phase 3 M14TIL trial randomized 168 patients with unrespectable stage IIIC-IV melanoma to immunotherapy with the anti-CTLA-4 antibody ipilimumab or to TIL treatment; most patients had failed prior anti-PD-1 treatment. Results reported for the first time at the ESMO Congress 2022 showed that patients treated with TIL therapy had significantly longer median progression-free survival of 7.2 months compared to 3.1 months in those receiving ipilimumab; the overall response rate to TILs was 49% versus 21% for ipilimumab; median overall survival was 25.8 months versus 18.9 months. Patients are still being followed up for overall survival.
"The results from this phase 3 study could potentially lead to regulatory approval that would be practice changing," said the researchers.
Ref:
JOURNAL Annals of Oncology, MEETING ESMO Congress 2022
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