Protein that may help protect against osteoporosis identified
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New research published in The FASEB Journal indicates that increasing the expression of a particular gene may help to prevent bone loss associated with postmenopausal osteoporosis. Postmenopausal osteoporosis is a medical condition characterized by a decrease in bone density and strength that occurs after menopause.
For the study, investigators examined which genes are involved in turning precursor cells called bone marrow–derived mesenchymal stem cells (BMSCs) into cells that play a crucial role in bone formation. The screen identified a gene that encodes high mobility group AT-hook 1 (Hmga1), a protein that controls the expression of a variety of other genes.
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