Lung transplantation in India- The cost effective way
The Standard donor lung preservation technique with cold flush and storage allows up to six hours between retrieval of lungs from the donor and transplantation in the recipient. Ex vivo lung perfusion (EVLP) systems mimic physiological ventilation and perfusion in the donor lungs with potential for prolonged lung preservation and donor lung reconditioning.
The present study that I am mentioning here aimed to perform Ex vivo lung perfusion on discarded donor lungs using a locally developed Ex vivo lung perfusion system. The study is published in Indian Journal of Medical Research.
So for the study, equipment that are routinely used for cardiac surgeries were collected and a functional Ex vivo lung perfusion system was assembled. This system was used on five pairs of lungs retrieved from brain-dead organ donors. The lungs were ventilated and pulmonary circulation was continuously perfused with a solution containing oxygen and nutrients for four hours. The system was tested without red blood cells (RBCs) added to the solution and also with RBCs added to the solution.
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