New Study Backs Tacrolimus Over Cyclosporine in Preventing Lung Transplant Complications
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A new study published in the Journal of Heart and Lung Transplantation has found that lung transplant recipients treated with twice-daily tacrolimus have significantly lower rates of chronic lung allograft dysfunction (CLAD) and better overall survival compared to those receiving cyclosporine. The findings are based on data from over 22,000 patients in the International Society for Heart and Lung Transplantation Thoracic Organ Transplant Registry.
CLAD is a major long-term complication following lung transplantation, leading to progressive and irreversible loss of graft function. Immunosuppressive medications such as calcineurin inhibitors—tacrolimus and cyclosporine—are widely used to help prevent rejection. However, whether one drug is more effective than the other had remained uncertain.
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