This multi-society collaboration utilized modified GRADE methodology and clinical consensus to formulate its recommendations. The process included a comprehensive review of existing literature, supplemental searches, and a robust stakeholder feedback system.
Given the limited number of high-quality studies on BZD tapering strategies, most of the recommendations are based on clinical expertise and experience rather than randomized controlled trials. Nonetheless, the guideline provides a much-needed framework for healthcare providers navigating the complex process of benzodiazepine discontinuation, particularly in vulnerable populations.
Key Recommendations for Benzodiazepine Tapering:
• Assess ongoing risks and benefits:
Providers should continuously evaluate whether the risks of ongoing BZD use outweigh the therapeutic advantages. Tapering should be initiated when the balance shifts toward harm.
• Identify high-risk patients for frequent review:
Special consideration is needed for individuals taking opioids, those with substance use disorders, co-existing physical or mental health conditions, pregnant patients, and adults over 65.
• Engage in shared decision-making:
Treatment plans should be made collaboratively with patients and their caregivers to ensure transparency and adherence.
• Avoid abrupt discontinuation:
Sudden cessation of BZDs in physically dependent patients can lead to serious withdrawal. A gradual taper is essential.
• Outpatient vs inpatient care:
While most patients can taper in an outpatient setting, those with higher risk should be considered for inpatient or residential care.
• Tapering pace and flexibility:
Start with dose reductions of 5–10% every 2–4 weeks. For long-term users or those with complications, tapering might need to extend over months or years.
• Tailor the taper to individual response:
Adjust the taper speed as needed, and consider switching to a longer-acting BZD for smoother reductions.
• Psychosocial support:
Cognitive behavioral therapies, especially for insomnia, can ease the tapering process and reduce withdrawal symptoms.
• Manage co-occurring disorders:
Simultaneous treatment for psychiatric or physical conditions that may complicate tapering is recommended.
• Incorporate harm reduction:
Provide naloxone where needed, educate patients about risks, and connect them with relevant resources.
Despite the lack of robust controlled studies on benzodiazepine tapering, this guideline fills a critical gap by offering a structured, consensus-based approach for clinicians. It also calls for further research to strengthen the evidence base and optimize patient safety and outcomes in BZD management.
Reference:
Brunner, E., Chen, CY.A., Klein, T. et al. Joint Clinical Practice Guideline on Benzodiazepine Tapering: Considerations When Risks Outweigh Benefits. J GEN INTERN MED (2025). https://doi.org/10.1007/s11606-025-09499-2
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.