Rosuvastatin coprescription with canagliflozin tied to Statin toxicity
Written By : Hina Zahid
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2020-08-04 07:00 GMT | Update On 2023-10-17 10:35 GMT
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Researchers have found in a case study that Coprescription of rosuvastatin and canagliflozin may lead to Statin toxicity.
Physicians should be aware that canagliflozin could cause rosuvastatin toxicity when the two drugs are prescribed together. This is an important finding because these drugs are taken by millions of patients worldwide and are increasingly prescribed together. The first report of an interaction between these two drugs is published in Annals of Internal Medicine.
Rosuvastatin belongs to a group of medicines called HMG-CoA reductase inhibitors, or statins. It works by blocking an enzyme that is needed by the body to make cholesterol, so this reduces the amount of cholesterol in the blood.
Rosuvastatin is a commonly prescribed statin and canagliflozin is one of a newer class of diabetes drugs, the sodium-glucose cotransporter-2 (SGLT2) inhibitors. It is common for patients with diabetes to also take a statin. In fact, the American College of Cardiology currently recommends adding an SGLT2 inhibitor, such as canagliflozin, to the regimens of patients with diabetes and cardiovascular disease.
For more details click on the link: https://www.acpjournals.org/doi/10.7326/L20-0549
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