DOACs associated with lower mortality in comparison to Warfarin, Finds study
Among US nursing home residents, the direct-acting oral anticoagulants (DOACs) were each associated with lower mortality versus warfarin, according to recent research published in the Journal of General Internal Medicine.
"Misaligned DOAC dosing was common in nursing homes and was associated with clinical and mortality outcomes", exclaims Matthew Alcusky, the lead author from the Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
Research comparing direct-acting oral anticoagulants (DOACs) to warfarin has excluded nursing home residents, a vulnerable and high-risk population. Therefore, the researchers carried out this study to compare the safety and effectiveness of DOACs versuswarfarin.
This new-user cohort study went on from 2011-2016 where US nursing home residents aged > 65 years with non-valvular atrial fibrillation were enrolled in fee-for-service Medicare for > 6 months. The initiators of DOACs (2881 apixaban, 1289 dabigatran, 3735 rivaroxaban) were 1:1 propensity-matched to warfarin initiators.
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