Even Low dose diclofenac not risk neutral for cardiovascular events
Even Low dose diclofenac is not risk neutral for cardiovascular events suggests a new study published in the European Heart Journal - Cardiovascular Pharmacotherapy
A study was done to examine the dose dependency of diclofenac's cardiovascular risks.
Using Danish health registries and the target trial emulation design, we conducted a series of 300 nationwide cohort studies during 1996–2020, each mimicking the strict design criteria of a clinical trial. Adults eligible for inclusion had no recent non-steroidal anti-inflammatory drug prescriptions, contraindications (gastrointestinal diseases, thrombocytopenia, or heart failure), or conditions with low adherence (dementia or psychiatric disease). Diclofenac initiators were compared to healthcare-seeking non-initiators and head-to-head using an approximated high dose of ≥150 mg/day vs. low dose of <150 mg/day. Cox regression was used to compute the incidence rate ratio (IRR) of major adverse cardiovascular events (MACE) within 30 days following initiation. They adjusted for age, sex, calendar period, comorbidity, comedication, and socioeconomic position.
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