Even short course of Oral steroids tied to severe adverse events: Study

The main points of measurements were Incidence rates of severe adverse events in steroid burst users and non–steroid users, as well as incidence rate ratios (IRRs) for severe adverse events within 5 to 30 and 31 to 90 days after initiation of steroid therapy.

The key findings of the study were as follows:

• Of 15 859 129 adult participants, 2 623 327 who received a single steroid burst were included.
• The most common indications were skin disorders and respiratory tract infections.
• The incidence rates per 1000 person-years in steroid bursts were 27.1 for GI bleeding, 1.5 for sepsis, and 1.3 for heart failure.
• Rates of GI bleeding, sepsis, and heart failure significantly increased within 5 to 30 days after steroid therapy initiation and attenuated during the subsequent 31 to 90 days.
• The main limitation of the study were not including participants younger than 20 years or older than 64 years.

Thus, the researchers concluded that Oral corticosteroid bursts which are frequently prescribed in the general adult population in Taiwan caused the highest rates of GI bleeding, sepsis, and heart failure within the first month after initiation of steroid therapy. 

To read about the study, click the following link: https://doi.org/10.7326/M20-0432